Lab Invest 2008;88(5):541-552. J Dairy Sci 2009;92(3):1023-1037. Microbiology 2009;155(Pt 1):285-294. Chajes, V., Lavillonniere, F., Ferrari, P., Jourdan, M. L., Pinault, M., Maillard, V., Sebedio, J. L., and Bougnoux, P. Conjugated linoleic acid content in breast adipose tissue is not associated with the relative risk of breast cancer in a population of French patients. 3-30-2007;268(1-2):50-58. View abstract. Carcinogenesis 2006;27(5):972-981. 2000;22(3):433-449. J Dairy Sci 2008;91(3):1175-1188. J Nutr Biochem. View abstract. Konig, B., Spielmann, J., Haase, K., Brandsch, C., Kluge, H., Stangl, G. I., and Eder, K. Effects of fish oil and conjugated linoleic acids on expression of target genes of PPAR alpha and sterol regulatory element-binding proteins in the liver of laying hens. J Neurochem. J Dairy Res 2009;76(3):278-282. Carcinogenesis 2007;28(6):1329-1333. Am J Clin Nutr 2004;79:1118-25. Yanagita, T., Wang, Y. M., Nagao, K., Ujino, Y., and Inoue, N. Conjugated linoleic acid-induced fatty liver can be attenuated by combination with docosahexaenoic acid in C57BL/6N mice. View abstract. (Silver.Spring) 2008;16(10):2245-2252. Bleeding disorders. J Dairy Sci 2005;88(8):2923-2937. J Nutr 2005;135(2):239-244. A., Wu, H. C., Farquharson, A., Grant, I., Arthur, J. R., Rotondo, D., Choe, S. N., and Wahle, K. W. Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants. View abstract. View abstract. Devillard, E., McIntosh, F. M., Paillard, D., Thomas, N. A., Shingfield, K. J., and Wallace, R. J. Syvertsen, C., Halse, J., Hoivik, H. O., Gaullier, J. M., Nurminiemi, M., Kristiansen, K., Einerhand, A., O'Shea, M., and Gudmundsen, O. 2010;87(5):1737-1742. Cell Physiol Biochem. Truitt, A., McNeill, G., and Vanderhoek, J. Y. Antiplatelet effects of conjugated linoleic acid isomers. Taking safflower along with medications that also slow clotting might increase the chances of bruising and bleeding. 1-15-2009;128(3):467-472. View abstract. View abstract. Z. View abstract. Eggert, J. M., Belury, M. A., Kempa-Steczko, A., Mills, S. E., and Schinckel, A. P. Effects of conjugated linoleic acid on the belly firmness and fatty acid composition of genetically lean pigs. 9-2-2010; View abstract. J.Agric.Food Chem. Obes Res 2004;12(9):1435-1444. Murphy, E. F., Hooiveld, G. J., Muller, M., Calogero, R. A., and Cashman, K. D. The effect of trans-10, cis-12 conjugated linoleic acid on gene expression profiles related to lipid metabolism in human intestinal-like Caco-2 cells. A., Arevalo-Herrera, M., Shahabuddin, A. K., Ersheng, G., Herrera, S., Garcia, R. G., and Lopez-Jaramillo, P. Calcium and conjugated linoleic acid reduces pregnancy-induced hypertension and decreases intracellular calcium in lymphocytes. View abstract. 20:2delta(c11,t13/t12,c14)), eicosatrienoic (conj. Changhua, L., Jindong, Y., Defa, L., Lidan, Z., Shiyan, Q., and Jianjun, X. Conjugated linoleic acid attenuates the production and gene expression of proinflammatory cytokines in weaned pigs challenged with lipopolysaccharide. View abstract. Abdelqader, M. M., Hippen, A. R., Kalscheur, K. F., Schingoethe, D. J., and Garcia, A. D. Isolipidic additions of fat from corn germ, corn distillers grains, or corn oil in dairy cow diets. View abstract. Taking conjugated linoleic acid along with ramipril seems to increase the blood pressure-lowering effects of ramipril. J Nutr 2007;137(5):1200-1207. Anticancer Res 1998;18:1429-34. J Dairy Sci 2009;92(4):1378-1386. View abstract. Goua, M., Mulgrew, S., Frank, J., Rees, D., Sneddon, A. Chem.Biol.Interact. Ruth, M. R., Taylor, C. G., Zahradka, P., and Field, C. J. Abnormal immune responses in fa/fa Zucker rats and effects of feeding conjugated linoleic acid. Santillo, A., Quinto, M., Dentico, M., Muscio, A., Sevi, A., and Albenzio, M. Rennet paste from lambs fed a milk substitute supplemented with Lactobacillus acidophilus: effects on lipolysis in ovine cheese. A. Dietary conjugated linoleic acids alter serum IGF-I and IGF binding protein concentrations and reduce bone formation in rats fed (n-6) or (n-3) fatty acids. A., and Wahle, K. W. Regulation of adhesion molecule expression in human endothelial and smooth muscle cells by omega-3 fatty acids and conjugated linoleic acids: involvement of the transcription factor NF-kappaB? Badr El-Din, N. K. and Omaye, S. T. Concentration-dependent antioxidant activities of conjugated linoleic acid and alpha-tocopherol in corn oil. Drug interactions: Calcium can interfere with many medications, including prescription osteoporosis drugs known as bisphosphonates (such as alendronate), certain blood â¦ GNC claims that the product will burn fat and boost metabolism.While CLA (conjugated linoleic acid) has been proven to assist with weight loss, the Total Lean blend includes safflower oil, which is inferior for fighting fat. View abstract. A., Defnoun, S., and Jones, P. J. View abstract. Effect of cooking methods on fatty acids, conjugated isomers of linoleic acid and nutritional quality of beef intramuscular fat. 2007;189(6):2566-2570. Effects of two conjugated linoleic Acid isomers on body fat mass in overweight humans. Zhao, W. S., Zhai, J. J., Wang, Y. H., Xie, P. S., Yin, X. J., Li, L. X., and Cheng, K. L. Conjugated linoleic acid supplementation enhances antihypertensive effect of ramipril in Chinese patients with obesity-related hypertension. Effect of dietary conjugated linoleic acid on phorbol ester-induced PGE2 production and hyperplasia in mouse epidermis. Mitchell, P. L., Langille, M. A., Currie, D. L., and McLeod, R. S. Effect of conjugated linoleic acid isomers on lipoproteins and atherosclerosis in the Syrian Golden hamster. View abstract. Comp Biochem.Physiol B Biochem.Mol.Biol 2002;133(3):395-404. Inoue, N., Nagao, K., Hirata, J., Wang, Y. M., and Yanagita, T. Conjugated linoleic acid prevents the development of essential hypertension in spontaneously hypertensive rats. Smit, L. A., Willett, W. C., and Campos, H. trans-fatty acid isomers in adipose tissue have divergent associations with adiposity in humans. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. Cherian, G., Traber, M. G., Goeger, M. P., and Leonard, S. W. Conjugated linoleic acid and fish oil in laying hen diets: effects on egg fatty acids, thiobarbituric acid reactive substances, and tocopherols during storage. Orlistat is a gastrointestinal lipase inhibitor that works by blocking absorption of 25% of the fat in a meal and is used for weight loss in overweight adults, 18 years and older, when used along with a reduced-calorie and low-fat diet.. Orlistat is available under the following different brand names: Alli, and Xenical. View abstract. Mohammed, R., Stanton, C. S., Kennelly, J. J., Kramer, J. K., Mee, J. F., Glimm, D. R., O'Donovan, M., and Murphy, J. J. Grazing cows are more efficient than zero-grazed and grass silage-fed cows in milk rumenic acid production. Gross, S., Iannone, R., Xiao, S., and Bertram, A. K. Reactive uptake studies of NO3 and N2O5 on alkenoic acid, alkanoate, and polyalcohol substrates to probe nighttime aerosol chemistry. View abstract. View abstract. Al Darwich, A., Perreau, C., Petit, M. 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Carcinogenesis 1987;8(12):1881-1887. View abstract. View abstract. DNA Seq. Bocca, C., Bozzo, F., Gabriel, L., and Miglietta, A. Conjugated linoleic acid inhibits Caco-2 cell growth via ERK-MAPK signaling pathway. J Dairy Sci 2009;92(9):4317-4329. J Dairy Sci 2007;90(8):3786-3801. 8-12-2009;57(15):7125-7130. Mir, P. S., Dugan, M. E., He, M. L., Entz, T., and Yip, B. Effect of the degree of processing on soy oil conjugated linoleic acid yields. Br.J Nutr 2007;98(4):860-867. Burdge, G. C., Lupoli, B., Russell, J. J., Tricon, S., Kew, S., Banerjee, T., Shingfield, K. J., Beever, D. E., Grimble, R. F., Williams, C. M., Yaqoob, P., and Calder, P. C. Incorporation of cis-9,trans-11 or trans-10,cis-12 conjugated linoleic acid into plasma and cellular lipids in healthy men. View abstract. J Dairy Sci 2009;92(1):392-400. B. Conjugated linoleic acid conversion by dairy bacteria cultured in MRS broth and buffalo milk. 7-10-2001;168(1):15-21. Current Nutrition & Food Science 2009;5(3):209-216. Cancer Lett 12-8-2003;202(1):81-87. 2007;44(5):467-474. View abstract. View abstract. Effect of inoculated corn silage enriched with sunflower oil on rumen fermentation and lipid metabolism in an artificial rumen (RUSITEC). Nutr Cancer 2000;38:151-7. Field, C. J. and Schley, P. D. Evidence for potential mechanisms for the effect of conjugated linoleic acid on tumor metabolism and immune function: lessons from n-3 fatty acids. Br.J Nutr 2009;102(6):803-815. An increase in vitamin A status by the feeding of conjugated linoleic acid. Cell Prolif. View abstract. Regulation of osteoblast and adipocyte differentiation from human mesenchymal stem cells by conjugated linoleic acid. View abstract. View abstract. 2009;89(3-4):66-72. A. and Holmes, L. D. Diet supplementation with fish oil and sunflower oil to increase conjugated linoleic acid levels in milk fat of partially grazing dairy cows. Kelley, D. S., Taylor, P. C., Rudolph, I. L., Benito, P., Nelson, G. J., Mackey, B. E., and Erickson, K. L. Dietary conjugated linoleic acid did not alter immune status in young healthy women. Reynolds, C. M., Draper, E., Keogh, B., Rahman, A., Moloney, A. P., Mills, K. H., Loscher, C. E., and Roche, H. M. A conjugated linoleic acid-enriched beef diet attenuates lipopolysaccharide-induced inflammation in mice in part through PPARgamma-mediated suppression of toll-like receptor 4. View abstract. 8-30-2007;169(2):110-121. Cancer Lett 6-24-1997;116(2):121-130. 3-12-2008;56(5):1654-1660. Maurelli, S., Blasi, F., Cossignani, L., Bosi, A., Simonetti, M. S., and Damiani, P. Enzymatic Synthesis of Structured Triacylglycerols Containing CLA Isomers Starting from sn-1,3-Diacylglycerols. Bergamo, P., Luongo, D., and Rossi, M. Conjugated linoleic acid--mediated apoptosis in Jurkat T cells involves the production of reactive oxygen species. View abstract. Soel, S. M., Choi, O. S., Bang, M. H., Yoon Park, J. H., and Kim, W. K. Influence of conjugated linoleic acid isomers on the metastasis of colon cancer cells in vitro and in vivo. Total antioxidant capacity of arginine-conjugated linoleic acid (CLA) complex. Br.J Nutr 2007;97(2):289-297. Miller, A., Stanton, C., and Devery, R. Cis 9, trans 11- and trans 10, cis 12-conjugated linoleic acid isomers induce apoptosis in cultured SW480 cells. Huot, P. S., Sarkar, B., and Ma, D. W. Conjugated linoleic acid alters caveolae phospholipid fatty acid composition and decreases caveolin-1 expression in MCF-7 breast cancer cells. Effect of supplementation with conjugated linoleic acid on human serum lipids and body fat. Some people may experience mild to moderate side effects, including stomach upset, diarrhea, and nausea.15ï»¿ Conjugated linoleic acid may also slow blood clotting. View abstract. Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Clin Chim.Acta 8-28-1998;276(2):163-172. Meat.Sci 10-17-2008; View abstract. 2009;84(1):87-97. View abstract. Different oilseed supplements alter fatty acid composition of different adipose tissues of adult ewes. Different mechanisms of cis-9,trans-11- and trans-10,cis-12- conjugated linoleic acid affecting lipid metabolism in 3T3-L1 cells. Ens JG, Ma DW, Cole KS, et al. J Sci Food Agric. View abstract. J Nutr Biochem. Leone, V. A., Worzalla, S. P., and Cook, M. E. Body compositional changes and growth alteration in chicks from hens fed conjugated linoleic acid. 4-15-2009; View abstract. J Int Med Res 2001;29:392-6.. View abstract. Igarashi, M. and Miyazawa, T. The growth inhibitory effect of conjugated linoleic acid on a human hepatoma cell line, HepG2, is induced by a change in fatty acid metabolism, but not the facilitation of lipid peroxidation in the cells. Biochim.Biophys Acta 2-26-2001;1530(2-3):162-171. 3-27-1998;244(3):678-682. View abstract. J Agric.Food Chem. View abstract. Soyeurt, H. and Gengler, N. 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Effects of conjugated linoleic acid isomers on the hepatic microsomal desaturation activities in vitro. View abstract. View abstract. View abstract. Effect of dietary supplementation with conjugated linoleic acid, with oleic, linoleic, or linolenic acid, on egg quality characteristics and fat accumulation in the egg yolk. Iassonova, D., Hammond, E. G., and Beattie, S. E. Oxidative Stability of Polyunsaturated Triacylglycerols Encapsulated in Oleaginous Yeast. Int J Cancer 12-20-2004;112(6):909-919. 2009;19(12):1617-1619. View abstract. Platt, I., Rao, L. G., and El Sohemy, A. Isomer-specific effects of conjugated linoleic acid on mineralized bone nodule formation from human osteoblast-like cells. Schut, H. A. and Zu, H. X. View abstract. J Agric.Food Chem 11-30-2005;53(24):9629-9633. Puniya, A. K., Chaitanya, S., Tyagi, A. K., De, S., and Singh, K. Conjugated linoleic acid producing potential of lactobacilli isolated from the rumen of cattle. 2008;54(3):122-125. View abstract. A., and Belury, M. A. (Tokyo) 2005;51(1):8-15. A., Gonzalo, C., Arenas, R., Fresno, J. M., and San Primitivo, F. Factors influencing variation of fatty acid content in ovine milk. J Lipid Res 2008;49(3):550-562. View abstract. Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider. Dauchy, R. T., Dauchy, E. M., Sauer, L. A., Blask, D. E., Davidson, L. K., Krause, J. View abstract. Ringseis, R., Muschick, A., and Eder, K. Dietary oxidized fat prevents ethanol-induced triacylglycerol accumulation and increases expression of PPARalpha target genes in rat liver. Churruca, I., Fernandez-Quintela, A., Zabala, A., Macarulla, M. T., Navarro, V., Rodriguez, V. M., Simon, E., Milagro, F., and Portillo, M. P. The effect of trans-10,cis-12 conjugated linoleic acid on lipogenesis is tissue dependent in hamsters. Flowers, G., Ibrahim, S. A., and AbuGhazaleh, A. View abstract. 1999;63(6):1104-1106. View abstract. Watkins, B. J Obes. 8-12-2009;57(15):6524-6527. Growth Horm.IGF.Res 2008;18(5):361-368. Biochem Biophys Res Commun. J Anim Sci 2009;87(7):2299-2305. AbuGhazaleh, A. J Nutr 2009;139(10):1861-1866. J Nutr 2009;139(10):1867-1872. HCA drug interactions are not known at this time, because the supplement has not been studied in combination with drugs or other supplements. Biochim.Biophys Acta 12-30-2003;1635(2-3):75-82. View abstract. Effect of a high intake of conjugated linoleic acid on lipoprotein levels in healthy human subjects. View abstract. 2010;48(2):587-590. Tholstrup, T., Raff, M., Straarup, E. M., Lund, P., Basu, S., and Bruun, J. M. An oil mixture with trans-10, cis-12 conjugated linoleic acid increases markers of inflammation and in vivo lipid peroxidation compared with cis-9, trans-11 conjugated linoleic acid in postmenopausal women. View abstract. View abstract. View abstract. Pinkoski, C., Chilibeck, P. D., Candow, D. G., Esliger, D., Ewaschuk, J. Br J Nutr 2005;94(5):791-795. View abstract. Shingfield, K. J., Rouel, J., and Chilliard, Y. Ou, L., Wu, Y., Ip, C., Meng, X., Hsu, Y. C., and Ip, M. M. Apoptosis induced by t10,c12-conjugated linoleic acid is mediated by an atypical endoplasmic reticulum stress response. For now, if you're looking to lose weight, there's not enough evidence to show that taking CLA will help. View abstract. Park, Y., Albright, K. J., Liu, W., Storkson, J. M., Cook, M. E., and Pariza, M. W. Effect of conjugated linoleic acid on body composition in mice. A. Fatty acid composition of milk from multiparous Holstein cows treated with bovine somatotropin and fed n-3 fatty acids in early lactation. J Dairy Sci 2008;91(8):3119-3127. View abstract. Or-Rashid, M. M., Odongo, N. E., and McBride, B. W. Fatty acid composition of ruminal bacteria and protozoa, with emphasis on conjugated linoleic acid, vaccenic acid, and odd-chain and branched-chain fatty acids. 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The effect of dietary fiber level on milk fat concentration and fatty acid profile of cows fed diets containing low levels of polyunsaturated fatty acids. Int.J.Obes. Nam, I. S. and Garnsworthy, P. C. Factors influencing biohydrogenation and conjugated linoleic acid production by mixed rumen fungi. Rasooly, R., Kelley, D. S., Greg, J., and Mackey, B. E. Dietary trans 10, cis 12-conjugated linoleic acid reduces the expression of fatty acid oxidation and drug detoxification enzymes in mouse liver. Prostaglandins Leukot.Essent.Fatty Acids 2008;78(1):33-43. Nutr Neurosci. Valente, L. M., Bandarra, N. M., Figueiredo-Silva, A. C., Rema, P., Vaz-Pires, P., Martins, S., Prates, J. J Microbiol. 2009;20(11):848-59, 859. View abstract. Chem.Phys.Lipids 2008;154(2):105-114. View abstract. A., Carne, X., Vidal, S., Mas, S., Deulofeu, R., and Lafuente, A. View abstract. Physiol Genomics 5-13-2009;37(3):187-198. Res Vet.Sci 2010;89(2):191-195. View abstract. 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Dietary supplementation with conjugated linoleic acid increased its concentration in human peripheral blood mononuclear cells, but did not alter their function. Occurrence of Conjugated Linolenic Acids in Purified Soybean Oil. Biochem.Biophys.Res Commun. ed., The Gale Encyclopedia of Alternative Medicine, third edition, 2009. J Nutr Biochem. Appl.Physiol Nutr Metab 2008;33(6):1096-1104. Meat.Sci 2010;85(1):59-65. View abstract. Yamasaki, M., Kishihara, K., Mansho, K., Ogino, Y., Kasai, M., Sugano, M., Tachibana, H., and Yamada, K. Dietary conjugated linoleic acid increases immunoglobulin productivity of Sprague-Dawley rat spleen lymphocytes. Arch.Anim Nutr 2007;61(5):406-415. View abstract. Lipids Health Dis. Lipids 2001;36:773-81. J Lipid Res 1999;40(8):1426-1433. 8-27-2008;56(16):7208-7214. View abstract. West DB, Delany JP, Camet PM, et al. Genes Nutr 2008;3(3-4):127-137. Toral, P. G., Shingfield, K. J., Hervas, G., Toivonen, V., and Frutos, P. 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Takahashi, K., Akiba, Y., Iwata, T., and Kasai, M. Effect of a mixture of conjugated linoleic acid isomers on growth performance and antibody production in broiler chicks. Cho, H. J., Kwon, G. T., and Park, J. H. trans-10,cis-12 Conjugated linoleic acid induces depolarization of mitochondrial membranes in HT-29 human colon cancer cells: a possible mechanism for induction of apoptosis. View abstract. Mammary Cancer prevention Reproduction & Infertility 2009 ; 139 ( 10 ).. Double bond isomerases producing conjugated linoleic acid ( CLA cla drug interactions, and erickson K.! Oxidation products ( green odor ) on rumen biohydrogenation and conjugated linoleic acid trans... Distribution on Physicochemical properties of conjugated linoleic acid content of human MCF-7 and MDA-MB-231 ]: S612-S617 R.! Lower a person 's weight or BMI rumen fungi AbuGhazaleh, a siddiqui, R., Miglietta... Exploitation of dietary supplementation with conjugated linoleic acid in humans: regulation the. 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